ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (Internal Region) antibody

Details for Product No. ABIN1731529
Antigen
Epitope
Internal Region
30
15
12
9
8
8
7
6
6
4
3
3
3
2
1
1
1
1
1
Reactivity
Human
138
64
50
10
9
7
6
5
4
3
3
3
3
1
Host
Rabbit
126
21
4
Clonality
Polyclonal
Conjugate
Un-conjugated
10
7
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
90
38
33
29
15
13
5
4
3
2
1
1
Options
Immunogen Synthetic 19 amino acid peptide from internal region of human ADAMTS4. Percent identity with other species by BLAST analysis: Human (100%), Orangutan (100%), Gibbon (100%), Marmoset (100%), Dog (100%), Bat (100%), Panda (100%), Horse (100%)
Isotype IgG
Specificity Reacts with human ADAMTS4
Cross-Reactivity (Details) BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAMTS8 (53 % ).
Purification Antigen affinity purified
Antigen
Alternative Name ADAMTS4 (ADAMTS4 Antibody Abstract)
Background Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
UniProt O75173
Application Notes

Working dilution: IHC - P (2.6 μg/mL)

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, Sodium azide 0.1 %
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
Supplier Images
Image no. 1 for anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (Internal Region) antibody (ABIN1731529) anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (Internal Region) antibody