AGT antibody (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8)) (Internal Region)

Details for Product anti-AGT Antibody No. ABIN1731608
Antigen
Epitope
Internal Region
22
15
15
10
8
6
5
4
4
4
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
224
75
67
3
2
2
2
2
2
1
1
Host
Rabbit
196
65
2
Clonality
Polyclonal
Conjugate
This AGT antibody is un-conjugated
21
14
6
6
6
6
6
6
5
3
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
155
99
71
33
26
16
15
14
10
8
8
4
4
3
1
1
Options
Immunogen Synthetic 13 amino acid peptide from internal region of human AGT / Angiotensinogen. Percent identity with other species by BLAST analysis: Human (100%), Chimpanzee (100%), Gorilla (100%), Orangutan (100%), Gibbon (100%), Monkey (100%), Marmoset (85%).
Isotype IgG
Specificity Reacts with human AGT / Angiotensinogen
Cross-Reactivity (Details) BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purification Antigen affinity purified
Antigen
Alternative Name AGT / Angiotensinogen (AGT Antibody Abstract)
Background Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
UniProt P01019
Pathways JAK-STAT Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Monocarboxylic Acid Catabolic Process, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes

Working dilution: IHC - P (2.5 - 5 μg/mL)

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, Sodium azide 0.1 %
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-80 °C
Storage Comment Long term: -70°C, Short term: +4°C
Supplier Images
Image no. 1 for anti-Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (Internal Region) antibody (ABIN1731608) anti-Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (Internal Region) antibody