APH1A antibody (Anterior Pharynx Defective 1 Homolog A (C. Elegans))

Details for Product anti-APH1A Antibody No. ABIN1731862
Antigen
Reactivity
Human, Mouse (Murine)
95
56
26
1
1
1
1
1
Host
Rabbit
94
8
Clonality
Polyclonal
Conjugate
This APH1A antibody is un-conjugated
8
7
6
5
5
5
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
81
54
25
14
13
5
1
1
1
Options
Immunogen Synthetic peptide from human APH1A.
Isotype IgG
Specificity Reacts with 13 amino acid peptide from near the amino terminus of human APH1a
Purification Antigen affinity purified
Antigen
Alternative Name APH1A (APH1A Antibody Abstract)
Background Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the APH-1 family. Implicated in Notch signaling pathway.
UniProt Q96BI3
Pathways Notch Signaling, Neurotrophin Signaling Pathway
Application Notes

Working dilution: IHC - P (3, 2.5 μg/mL), WB

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, Sodium azide 0.02 %
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Supplier Images
Image no. 1 for anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) antibody (ABIN1731862) anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) antibody