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PARK7/DJ1 antibody (Parkinson Protein 7) C-Term Primary Antibody

PARK7 Reactivity: Human, Monkey IHC (p), ELISA, WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN1737866
$701.80
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Delivery in 12 to 14 Business Days
  • Target See all PARK7/DJ1 (PARK7) Antibodies
    PARK7/DJ1 (PARK7)
    Binding Specificity
    • 27
    • 16
    • 16
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 115
    • 80
    • 60
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Monkey
    Host
    • 114
    • 19
    • 7
    • 1
    Goat
    Clonality
    • 111
    • 27
    Polyclonal
    Conjugate
    • 88
    • 13
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PARK7/DJ1 antibody is un-conjugated
    Application
    • 110
    • 55
    • 44
    • 34
    • 27
    • 23
    • 23
    • 19
    • 14
    • 13
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
    Specificity
    Reacts with the C-terminus part of human PARK7 / DJ-1
    Cross-Reactivity (Details)
    Variants (NP_001116849.1, NP_009193.2) encode the same protein.
    Purification
    Antigen affinity purified
    Immunogen
    Synthetic peptide C-AAQVKAPLVLKD from the C-terminus of human PARK7 / DJ-1 (NP_001116849.1, NP_009193.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Monkey (100%), Marmoset (100%), Mouse (92%)
  • Application Notes

    Working dilution: Optimal dilution should be determined by the end user.
    The following are guidelines only :
    ELISA (1:32000), IHC-P (3.75 μg/mL), WB (0.5 - 1 μg/mL)

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    TBS, pH 7.3, BSA 0.5 % , Sodium azide 0.02 %
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Minimize freezing and thawing.
  • Target
    PARK7/DJ1 (PARK7)
    Alternative Name
    PARK7 / DJ-1 (PARK7 Products)
    Synonyms
    dj1, zgc:103725, DJ-1, Dj1, DJ1, CAP1, SP22, parkinson protein 7, Parkinson disease (autosomal recessive, early onset) 7, Parkinsonism associated deglycase, park7, PARK7, Park7
    Background
    Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity.
    Gene ID
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
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