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KCNK3 antibody (AA 251-411) (Biotin)

KCNK3 Reactivity: Rat WB, IHC, ICC, IF Host: Mouse Monoclonal S374-48 Biotin
Catalog No. ABIN1741496
  • Target See all KCNK3 Antibodies
    KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))
    Binding Specificity
    • 15
    • 15
    • 12
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 251-411
    Reactivity
    • 49
    • 29
    • 21
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 52
    • 12
    Mouse
    Clonality
    • 52
    • 12
    Monoclonal
    Conjugate
    • 16
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KCNK3 antibody is conjugated to Biotin
    Application
    • 53
    • 26
    • 26
    • 16
    • 15
    • 13
    • 12
    • 6
    • 6
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    Detects ~50 kDa. Does not cross-react with TASK3.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1. Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). <30% identity with TASK3.
    Clone
    S374-48
    Isotype
    IgG2b
    Top Product
    Discover our top product KCNK3 Primary Antibody
  • Application Notes
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN1741496 was sufficient for detection of TASK1 Potassium Channel in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))
    Alternative Name
    KCNK3 (KCNK3 Products)
    Synonyms
    si:dkey-164m15.1 antibody, K2p3.1 antibody, OAT1 antibody, PPH4 antibody, TASK antibody, TASK-1 antibody, TBAK1 antibody, cTBAK-1 antibody, Task-1 antibody, rTASK antibody, KCNK3 antibody, potassium channel, subfamily K, member 3a antibody, potassium two pore domain channel subfamily K member 3 antibody, potassium channel, subfamily K, member 3 antibody, kcnk3a antibody, KCNK3 antibody, Kcnk3 antibody
    Background
    K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions and include TWIK, TREK, TRAAK and TASK. TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54 % identity with TASK-1, but less than 30 % identity with TASK-2 and other tandem pore K+ channels.
    Gene ID
    29553
    NCBI Accession
    NP_203694
    UniProt
    O54912
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