GRIA1 antibody (Glutamate Receptor, Ionotropic, AMPA 1) (pSer845)

Details for Product anti-GRIA1 Antibody No. ABIN1741837, Supplier: Log in to see
Antigen
  • GLUH1
  • GLUR1
  • GLURA
  • GluA1
  • HBGR1
  • gluR-A
  • 2900051M01Rik
  • Glr-1
  • Glr1
  • GluR-A
  • GluRA
  • Glur-1
  • Glur1
  • HIPA1
  • gluR-K1
  • GRIA1
  • glur1
  • glutamate ionotropic receptor AMPA type subunit 1
  • glutamate receptor, ionotropic, AMPA1 (alpha 1)
  • glutamate receptor, ionotropic, AMPA 1
  • glutamate receptor, ionotropic, AMPA 1 L homeolog
  • GluR1 protein
  • Glutamate receptor 1
  • GRIA1
  • Gria1
  • gria1
  • gria1.L
  • glur1
  • glr-1
Alternatives
anti-Mouse (Murine) GRIA1 antibody for Western Blotting
Epitope
pSer845
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43
29
26
23
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17
15
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13
5
5
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4
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3
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3
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2
2
2
1
1
1
1
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1
1
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1
Reactivity
Rat (Rattus)
265
257
239
18
12
9
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7
4
2
2
2
1
1
Host
Rabbit
232
70
9
Clonality
Polyclonal
Conjugate
This GRIA1 antibody is un-conjugated
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8
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4
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3
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1
Application
Western Blotting (WB)
238
114
55
53
52
39
30
26
11
10
4
2
1
1
1
Options
Supplier
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Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding pSer845 conjugated to KLH.
Specificity Specific for the approx. 100 kDa GluR1 protein phosphorylated at Ser845 in Western blots of rat brain extracts. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is s completely eliminated by treatment with lambda-Ptase.
Predicted Reactivity Human,Mouse (Murine),Monkey
Purification Affinity purified
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Plasmids, Primers & others Plasmids, Primers & others GRIA1 products on genomics-online (e.g. as negative or positive controls)
Alternative Name GluR1 (GRIA1 Antibody Abstract)
Background Synonyms:
Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1, Gria1, Glur1
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990, Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. Phosphorylation of Ser845 on GluR1 is thought to be mediated by PKA and phosphorylation of this site increases the conductance of the AMPAR (Roche et al., 1996, Banke et al., 2000). In addition, phosphorylation of this site has been linked to synaptic plasticity as well as arning and memory (Lee at al., 2003, Esteban at al., 2003).
Molecular Weight 100 kDa
Gene ID 50592
UniProt P19490
Pathways PI3K-Akt Signaling
Application Notes Recommended Dilution:
WB approx. 1:1000
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) (pSer845) antibody (ABIN1741837) Western blot of rat hippocampal lysate showing specific immunolabeling of the 100 kDa...
Product cited in: Song, Massenburg, Wenderski, Jayaraman, Thompson, Neves: "ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 38, pp. 15437-42, 2013 (PubMed).

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