DcR1 antibody (FITC)

Catalog No. ABIN181101

Product Details anti-DcR1 Antibody (FITC)

Target: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DcR1 antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificity: This antibody recognises CD263, a 60 kDa cell surface protein.

Characteristics: Synonyms: Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3, Tumor necrosisfactor receptor superfamily member 10C, Decoy TRAIL receptor without death domain,TNF-related apoptosis-inducing ligand receptor 3, Trail receptor without an intracellulardomain, Lymphocyte inhibitor of TRAIL, Antagonist decoy receptor for TRAIL/Apo-2L

Purification: Affinity chromatography on Protein G

Immunogen: DcR1-Fc chimaeric protein. Lymph node cells from immunised mice were fused with cells ofthe P3U1 myeloma cell line.

Clone: 2B8

Isotype: IgG1

Application Details

Application Notes: Flow cytometry (Neat - 1/10): use 10 μL of the suggested working dilution to label 1x10^6cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for DcR1

Target: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Alternative Name: CD263 / TRAILR3 (TNFRSF10C Products)

Synonyms: CD263 antibody, DCR1 antibody, DCR1-TNFR antibody, LIT antibody, TRAIL-R3 antibody, TRAILR3 antibody, TRID antibody, TNFRSF10C antibody, TNF receptor superfamily member 10c antibody, TNFRSF10C antibody

Background: CD263 is a member of the tumour necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL). As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, but instead plays an important role in inhibiting TRAIL-induced apoptosis. CD263 is expressed in normal tissues including heart, skeletal tissues and peripheral blood neutrophils, but weakly expressed in tumour cells.Synonyms: Antagonist decoy receptor for TRAIL/Apo-2L, DCR1, Decoy TRAIL receptor without death domain, Decoy receptor 1, LIT, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TNFRSF10C, TRAIL receptor 3, TRAIL-R3, TRID, Trail receptor without an intracellular domain, Tumor necrosis factor receptor superfamily member 10C

Gene ID: 8794

UniProt: O14798

Pathways: Apoptosis