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ABCA4 antibody (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4) (AA 1450-1500) Primary Antibody

ABCA4 Reactivity: Human IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1841983
$454.67
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100 μL
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  • Target
    ABCA4
    Binding Specificity
    AA 1450-1500
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human
    • 30
    • 10
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Host
    Rabbit
    • 23
    • 8
    • 4
    Clonality
    Polyclonal
    • 32
    • 3
    Conjugate
    This ABCA4 antibody is un-conjugated
    • 21
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Immunohistochemistry (IHC), Western Blotting (WB)
    • 22
    • 15
    • 12
    • 1
    • 1
    • 1
    Specificity
    Specific for ABCA4.
    Purification
    Whole serum
    Immunogen
    A synthetic peptide from aa region 1450-1500 of human ABCA4 conjugated to an immunogenic carrier protein was used as the antigen.
  • Application Notes
    A dilution of 1 : 300 to 1 : 2000 is recommended.
    The optimal dilution should be determined by the end user.
    Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    ABCA4
    Alternative Name
    ABCA4 (ABCA4 Antibody Abstract)
    Synonyms
    ABC10, ABCR, ARMD2, CORD3, FFM, RMP, RP19, STGD, STGD1, AW050280, Abc10, Abcr, D430003I15Rik, RmP, abcr, ffm, rmp, rp19, stgd, abc10, armd2, cord3, stgd1, zgc:91823, ATP binding cassette subfamily A member 4, ATP-binding cassette, sub-family A (ABC1), member 4, ATP binding cassette subfamily A member 4 L homeolog, ATP-binding cassette, sub-family A (ABC1), member 4a, ABCA4, Abca4, abca4, abca4.L, abca4a
    Background
    FUNCTION: In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. Subcellular location: Membrane, Multi-pass membrane protein. Note: Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor. Tissue specificity: Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
    Synonyms: Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein, ABCR
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