FUNCTION: Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. Overexpression in multiple cell lines generates robust mechanosensitive cation currents that are non-selective, exhibit a linear current voltage relationship, and are sensitive to ruthenium red and gadolinium. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane, Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane, Multi-pass membrane protein Tissue specificity: Expressed in bladder, colon, kidney, lung, and skin.
Synonyms: Piezo type mechanosensitive ion channel component 1, PIEZO1