Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ABCC1 antibody (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1) Primary Antibody

ABCC1 Reactivity: Human, Mouse, Rat, Monkey Func, FACS, IF, IP Host: Mouse Monoclonal QCRL4 unconjugated
Catalog No. ABIN187367
$817.67
Plus shipping costs $45.00
1 mL
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target
    ABCC1
    Reactivity
    • 80
    • 14
    • 14
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Monkey
    Host
    • 46
    • 33
    • 3
    • 1
    Mouse
    Clonality
    • 50
    • 33
    Monoclonal
    Conjugate
    • 41
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This ABCC1 antibody is un-conjugated
    Application
    • 66
    • 52
    • 40
    • 23
    • 16
    • 13
    • 9
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Functional Studies (Func), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
    Specificity
    QCRL-4 reacts with a conformation-dependent internal epitope of MRP1, a 190 kDa trans-membrane phosphoglycoprotein overexpressed in various human multidrug resistant tumor cell lines. QCRL-4 inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles and its epitope has been localized to the second nucleotide binding domain of MRP1 between amino acids 1294 and 1531. QCRL-4 does not cross-react with human MDR1 and MDR3 gene products. Species Reactivity: Human. May crossreact with monkey, mouse and rat. Others not tested.
    Sterility
    0.22 μm filtered
    Immunogen
    Non-denatured membranes prepared from the human small cell lung cancer cell line H69AR, which highly overexpresses MRP1.The hybridoma cell line was obtained by fusion of SP2/O mouse myeloma cells with spleen cells from an immunized mouse.
    Clone
    QCRL4
    Isotype
    IgG1
  • Application Notes
    Flow Cytometry: Use at a dilution of 1:20 - 1:40 after fixing cells in 0.5% paraformaldehyde, followed by fluorochrome conjugated anti-mouse reagent. Immunocytochemistry: Use on paraformaldehyde (0.5% in PBS) fixed cytospin preparations. Immunoprecipitation Western Blot: NOT REACTIVE Dot Blot: Non-denatured only, use at 1:10,000 dilution. Functional Activity: Transport inhibition. The optimal dilution for a specific application should be determined by the researcher.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    1 mL containing purified antibody (40 µg/mL IgG1) with 0.7% BSA and 0.1% NaN3 in PBS, 0.22 µM filtered.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Target
    ABCC1
    Alternative Name
    ABCC1 / MRP1 (ABCC1 Antibody Abstract)
    Synonyms
    ABC29, ABCC, GS-X, MRP, MRP1, Abcc1a, Abcc1b, Mdrap, Mrp1, Avcc1a, Mrp, ABCC13, ATP binding cassette subfamily C member 1, ATP-binding cassette, sub-family C (CFTR/MRP), member 1, multidrug resistance-associated protein 1, ABCC1, Abcc1, LOC100152428, LOC100346553
    Pathways
    SARS-CoV-2 Protein Interactome
You are here:
help Support