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IRAK2 antibody (Interleukin-1 Receptor-Associated Kinase 2) (AA 546-564) Primary Antibody

IRAK2 Reactivity: Human IHC (fro), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN187751
$825.00
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target
    IRAK2
    Binding Specificity
    • 25
    • 9
    • 9
    • 9
    • 9
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 546-564
    Reactivity
    • 100
    • 24
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 99
    • 6
    Rabbit
    Clonality
    • 92
    • 13
    Polyclonal
    Conjugate
    • 46
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRAK2 antibody is un-conjugated
    Application
    • 82
    • 62
    • 28
    • 14
    • 11
    • 9
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
    Specificity
    Binds IRAK2. Anti-IRAK2 has no cross response to IRAK. Species Reactivity: Human, other species not tested.
    Immunogen
    A peptide corresponding to amino acid 546 to 564 of human IRAK2.
  • Application Notes
    Immunohistochemistry: Use at 2 µg/mL Western blot: Use at a 1:500 to 1:1,000 dilution. The optimal dilution for a specific application should be determined by the researcher.
    Restrictions
    For Research Use only
  • Buffer
    Immunoaffinity chromatography purified IgG, 100 µg in 200 µL of PBS containing 0.02% sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Target
    IRAK2
    Alternative Name
    IRAK2 (IRAK2 Antibody Abstract)
    Synonyms
    IRAK-2, 6330415L08Rik, AI649099, interleukin 1 receptor associated kinase 2, interleukin-1 receptor-associated kinase 2, IRAK2, Irak2
    Background
    The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappabeta, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappabeta activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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