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GFRA2 antibody (GDNF Family Receptor alpha 2) Primary Antibody

GFRA2 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN187775
$825.00
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target
    GFRA2
    Reactivity
    • 60
    • 32
    • 27
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 57
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 57
    • 3
    Polyclonal
    Conjugate
    • 30
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GFRA2 antibody is un-conjugated
    Application
    • 44
    • 30
    • 13
    • 13
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    This antibody recognizes GFR alpha-2. Species Reactivity: Human, mouse and rat. Other species not tested.
  • Application Notes
    Western blot: Use at a dilution of 1:1000 to 1:2000. HeLa whole cell lysate can be used as positive control and a 52 kDa band should be detected. The optimal dilution for a specific application should be determined by the researcher.
    Restrictions
    For Research Use only
  • Buffer
    This antibody is supplied as purified IgG, 100 µg in 200 µl of PBS containing 0.02% sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Target
    GFRA2
    Alternative Name
    GFRA2 / GDNFR-beta (GFRA2 Antibody Abstract)
    Synonyms
    GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2, Retl2, NTNRALPHA, ntnra, retl2, trnr2, gdnfrb, nrtnr-alpha, gfra2, GDNF family receptor alpha 2, glial cell line derived neurotrophic factor family receptor alpha 2, GDNF family receptor alpha 2a, GFRA2, Gfra2, gfra2, gfra2a
    Background
    Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glyco-sylphosphatidylinositol-linked protein NTNR alpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNR alpha from human, rat, chicken and mouse have been cloned recently. NTNR alpha was also termed GDNFRbeta, Ret Ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2(TrnR2), and nominated as GFR alpha-2 recently. GFR alpha-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFR alpha-2 and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
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