GFRA2 antibody (GDNF Family Receptor alpha 2) Primary Antibody
- Human, Mouse, Rat
- This GFRA2 antibody is un-conjugated
- Western Blotting (WB)
- This antibody recognizes GFR alpha-2. Species Reactivity: Human, mouse and rat. Other species not tested.
anti-GDNF Family Receptor alpha 2 (GFRA2) (AA 301-360) antibody Primary Antibody
GFRA2 Reactivity: Human, Mouse, Rat ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB Host: Rabbit Polyclonal unconjugated
- Application Notes
- Western blot: Use at a dilution of 1:1000 to 1:2000. HeLa whole cell lysate can be used as positive control and a 52 kDa band should be detected. The optimal dilution for a specific application should be determined by the researcher.
- For Research Use only
- This antibody is supplied as purified IgG, 100 µg in 200 µl of PBS containing 0.02% sodium azide.
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 4 °C
- Alternative Name
- GFRA2 / GDNFR-beta (GFRA2 Antibody Abstract)
- GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2, Retl2, NTNRALPHA, ntnra, retl2, trnr2, gdnfrb, nrtnr-alpha, gfra2, GDNF family receptor alpha 2, glial cell line derived neurotrophic factor family receptor alpha 2, GDNF family receptor alpha 2a, GFRA2, Gfra2, gfra2, gfra2a
- Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glyco-sylphosphatidylinositol-linked protein NTNR alpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNR alpha from human, rat, chicken and mouse have been cloned recently. NTNR alpha was also termed GDNFRbeta, Ret Ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2(TrnR2), and nominated as GFR alpha-2 recently. GFR alpha-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFR alpha-2 and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.