BLOC1S3 antibody (C-Term)

Catalog No. ABIN1881114

This anti-BLOC1S3 antibody is a Rabbit Polyclonal antibody detecting BLOC1S3 in WB. Suitable for Human. This Primary Antibody has been cited in 3+ publications.

Quick Overview for BLOC1S3 antibody (C-Term) (ABIN1881114)

Target: BLOC1S3 (Biogenesis of Lysosomal Organelles Complex-1, Subunit 3 (BLOC1S3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BLOC1S3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41728

Product Details anti-BLOC1S3 Antibody

Binding Specificity: AA 176-202, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BLOC1S3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-202 amino acids from the C-terminal region of human BLOC1S3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BLOC1S3 antibody (ABIN1881114)

Seshadri, Fitzpatrick, Ikram, DeStefano, Gudnason, Boada, Bis, Smith, Carassquillo, Lambert, Harold, Schrijvers, Ramirez-Lorca, Debette, Longstreth, Janssens: "Genome-wide analysis of genetic loci associated with Alzheimer disease." in: JAMA : the journal of the American Medical Association, Vol. 303, Issue 18, pp. 1832-40, (2010) (PubMed).

Morgan, Pasha, Johnson, Ainsworth, Eady, Dawood, McKeown, Trembath, Wilde, Watson, Maher: "A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8)." in: American journal of human genetics, Vol. 78, Issue 1, pp. 160-6, (2005) (PubMed).

Starcevic, DellAngelica: "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28393-401, (2004) (PubMed).

Target Details for BLOC1S3

Target: BLOC1S3 (Biogenesis of Lysosomal Organelles Complex-1, Subunit 3 (BLOC1S3))

Alternative Name: BLOC1S3

Background: This gene encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism.

Molecular Weight: 21256

NCBI Accession: NP_997715

UniProt: Q6QNY0