COL10A1 antibody (N-Term)

Catalog No. ABIN1881220

Product Details anti-COL10A1 Antibody

Target: COL10A1 (Collagen, Type X, alpha 1 (COL10A1))

Binding Specificity: AA 29-58, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL10A1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This COL10A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human COL10A1.

Clone: RB40406

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-COL10A1 antibody (ABIN1881220)

Mäkitie, Susic, Cole: "Early-onset metaphyseal chondrodysplasia type Schmid associated with a COL10A1 frame-shift mutation and impaired trimerization of wild-type α1(X) protein chains." in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Vol. 28, Issue 11, pp. 1497-501, (2010) (PubMed).

Wang, Qiu, Ma, Xia, Zhu, Zhu: "Expression of Runx2 and type X collagen in vertebral growth plate of patients with adolescent idiopathic scoliosis." in: Connective tissue research, Vol. 51, Issue 3, pp. 188-96, (2010) (PubMed).

Videman, Saarela, Kaprio, Näkki, Levälahti, Gill, Peltonen, Battié: "Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing." in: Arthritis and rheumatism, Vol. 60, Issue 2, pp. 470-81, (2009) (PubMed).

Higashikawa, Saito, Ikeda, Kamekura, Kawamura, Kan, Oshima, Ohba, Ogata, Takeshita, Nakamura, Chung, Kawaguchi: "Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene." in: Arthritis and rheumatism, Vol. 60, Issue 1, pp. 166-78, (2009) (PubMed).

Zimmermann, Boeuf, Dickhut, Boehmer, Olek, Richter: "Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter." in: Arthritis and rheumatism, Vol. 58, Issue 9, pp. 2743-53, (2008) (PubMed).

Target Details for COL10A1

Target: COL10A1 (Collagen, Type X, alpha 1 (COL10A1))

Alternative Name: COL10A1 (COL10A1 Products)

Background: This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).

Molecular Weight: 66158

NCBI Accession: NP_000484

UniProt: Q03692