ING2 antibody (AA 112-141)

Catalog No. ABIN1881460

Product Details anti-ING2 Antibody

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Binding Specificity: AA 112-141

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ING2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ING2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-141 amino acids from the Central region of human ING2.

Clone: RB40520

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ING2 antibody (ABIN1881460)

Ythier, Larrieu, Binet, Binda, Brambilla, Gazzeri, Pedeux: "Sumoylation of ING2 regulates the transcription mediated by Sin3A." in: Oncogene, Vol. 29, Issue 44, pp. 5946-56, (2010) (PubMed).

Larrieu, Ythier, Binet, Brambilla, Brambilla, Sengupta, Pedeux: "ING2 controls the progression of DNA replication forks to maintain genome stability." in: EMBO reports, Vol. 10, Issue 10, pp. 1168-74, (2009) (PubMed).

Kumamoto, Fujita, Kurotani, Saito, Unoki, Hagiwara, Shiga, Bowman, Yanaihara, Okamura, Nagashima, Miyamoto, Takenoshita, Yokota, Harris: "ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression." in: International journal of cancer. Journal international du cancer, Vol. 125, Issue 6, pp. 1306-15, (2009) (PubMed).

Borkosky, Gunduz, Nagatsuka, Beder, Gunduz, Ali, Rodriguez, Cilek, Tominaga, Yamanaka, Shimizu, Nagai: "Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma." in: Journal of cancer research and clinical oncology, Vol. 135, Issue 5, pp. 703-13, (2009) (PubMed).

Unoki, Kumamoto, Robles, Shen, Zheng, Harris: "A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis." in: FEBS letters, Vol. 582, Issue 28, pp. 3868-74, (2008) (PubMed).

Target Details for ING2

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Alternative Name: ING2 (ING2 Products)

Background: This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.

Molecular Weight: 32808

NCBI Accession: NP_001555

UniProt: Q9H160

Pathways: Chromatin Binding, Autophagy, Negative Regulation of intrinsic apoptotic Signaling