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SEMA7A antibody (N-Term)

SEMA7A Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1881787
  • Target See all SEMA7A Antibodies
    SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))
    Binding Specificity
    • 15
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 178-202, N-Term
    Reactivity
    • 45
    • 31
    • 24
    • 6
    • 5
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 34
    • 12
    • 2
    Rabbit
    Clonality
    • 34
    • 14
    Polyclonal
    Conjugate
    • 27
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SEMA7A antibody is un-conjugated
    Application
    • 42
    • 16
    • 13
    • 13
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SEMA7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-202 amino acids from the N-terminal region of human SEMA7A.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SEMA7A Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Esnault, Torr, Bernau, Johansson, Kelly, Sandbo, Jarjour: "Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation." in: PLoS ONE, Vol. 12, Issue 1, pp. e0170207, (2017) (PubMed).

    Seltsam, Strigens, Levene, Yahalom, Moulds, Moulds, Hustinx, Weisbach, Figueroa, Bade-Doeding, DeLuca, Blasczyk: "The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens." in: Transfusion, Vol. 47, Issue 1, pp. 133-46, (2007) (PubMed).

    Yamada, Kubo, Takeshita, Harashima, Kawano, Mine, Sagawa, Sugamura, Itoh: "Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 7, pp. 4094-100, (1999) (PubMed).

    Angelisová, Drbal, Cerný, Hilgert, Horejsí: "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules." in: Immunobiology, Vol. 200, Issue 2, pp. 234-45, (1999) (PubMed).

    Lange, Liehr, Goen, Gebhart, Fleckenstein, Ensser: "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses." in: Genomics, Vol. 51, Issue 3, pp. 340-50, (1998) (PubMed).

  • Target
    SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))
    Alternative Name
    SEMA7A (SEMA7A Products)
    Synonyms
    2900057C09Rik antibody, CDw108 antibody, H-Sema-L antibody, M-Sema-L antibody, Semal antibody, CD108 antibody, H-SEMA-K1 antibody, JMH antibody, SEMAK1 antibody, SEMAL antibody, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A antibody, semaphorin 7A (John Milton Hagen blood group) antibody, Sema7a antibody, SEMA7A antibody
    Background
    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
    Molecular Weight
    74824
    NCBI Accession
    NP_001139501, NP_001139502, NP_003603
    UniProt
    O75326
    Pathways
    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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