IKBKB antibody

Catalog No. ABIN1882049

Product Details anti-IKBKB Antibody

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IKBKB antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This IKK beta antibody was raised using purified His-tagged recombinant full length human IKK beta.

Clone: 62AT992

Isotype: IgG1

Application Details

Application Notes: WB: 1:100~500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-IKBKB antibody (ABIN1882049)

Tarantino, Tinevez, Crowell, Boisson, Henriques, Mhlanga, Agou, Israël, Laplantine: "TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures." in: The Journal of cell biology, Vol. 204, Issue 2, pp. 231-45, (2014) (PubMed).

Sun, Wang, Zhao, Yu, Fan, Wang, Wang, Lu, Zhang, Fu, Yang: "Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21341-8, (2010) (PubMed).

Potter, Cordell, Barton, Daly, Hyrich, Mann, Morgan, Wilson, Isaacs: "Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways." in: Annals of the rheumatic diseases, Vol. 69, Issue 7, pp. 1315-20, (2010) (PubMed).

Niida, Tanaka, Kamitani: "Downregulation of active IKK beta by Ro52-mediated autophagy." in: Molecular immunology, Vol. 47, Issue 14, pp. 2378-87, (2010) (PubMed).

Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, (2010) (PubMed).

Lobry, Lopez, Israël, Weil: "Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 3, pp. 908-13, (2007) (PubMed).

Edwards: "Anticipation of disaster." in: Journal of the Royal Society of Medicine, Vol. 84, Issue 5, pp. 323, (1991) (PubMed).

Target Details for IKBKB

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Alternative Name: IKK beta (IKBKB Products)

Synonyms: ikk-beta antibody, ikk2 antibody, ikkb antibody, ikkbeta antibody, IKBKB antibody, IKKB antibody, CG4201 antibody, DIK antibody, DLAK antibody, DmIKK antibody, DmIKKBeta antibody, DmIKKb antibody, DmIKKbeta antibody, DmIkkbeta antibody, Dmel\\CG4201 antibody, Dmikkb antibody, Dmikkbeta antibody, IK antibody, IKK antibody, IKK-beta antibody, IKKb antibody, IKKbeta antibody, IRD-5 antibody, IRD5 antibody, Ik antibody, Ikkb antibody, Ikkbeta antibody, Ird-5 antibody, Ird5 antibody, LRK antibody, Lak antibody, anon-89Bd antibody, dIKK antibody, dIKK-beta antibody, dIKKbeta antibody, dLak antibody, dmIKKbeta antibody, ikk antibody, ird antibody, ird5/DmIkk[beta] antibody, IKK2 antibody, NFKBIKB antibody, AIM-1 antibody, AI132552 antibody, IKK-2 antibody, IKK[b] antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog antibody, inhibitor of nuclear factor kappa B kinase subunit beta antibody, I-kappaB kinase beta antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antibody, inhibitor of kappaB kinase beta antibody, ikbkb.L antibody, IKBKB antibody, ikbkb antibody, IKKbeta antibody, Ikbkb antibody

Background: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).

Molecular Weight: 86564

NCBI Accession: NP_001177649, NP_001229707, NP_001547

UniProt: O14920

Pathways: NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins