RPS6KA6 antibody (N-Term)

Catalog No. ABIN1882127

Product Details anti-RPS6KA6 Antibody

Target: RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))

Binding Specificity: AA 15-45, N-Term

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KA6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human RSK4.

Clone: RB0894

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-RPS6KA6 antibody (ABIN1882127)

Sulzmaier, Young-Robbins, Jiang, Geerts, Prechtl, Matter, Kesari, Ramos: "RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics." in: Oncotarget, Vol. 7, Issue 48, pp. 79869-79884, (2018) (PubMed).

Thakur, Sun, Bollig, Wu, Biliran, Banerjee, Sarkar, Liao: "Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 14, pp. 4427-36, (2008) (PubMed).

Yntema, van den Helm, Kissing, van Duijnhoven, Poppelaars, Chelly, Moraine, Fryns, Hamel, Heilbronner, Pander, Brunner, Ropers, Cremers, van Bokhoven: "A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation." in: Genomics, Vol. 62, Issue 3, pp. 332-43, (2000) (PubMed).

Target Details for RPS6KA6

Target: RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))

Alternative Name: RSK4 (RPS6KA6 Products)

Synonyms: PP90RSK4 antibody, RSK4 antibody, 2610524K04Rik antibody, RGD1560817 antibody, ribosomal protein S6 kinase A6 antibody, ribosomal protein S6 kinase polypeptide 6 antibody, RPS6KA6 antibody, Rps6ka6 antibody

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).

Molecular Weight: 83872

NCBI Accession: NP_055311

UniProt: Q9UK32

Pathways: MAPK Signaling