SUMO2 antibody

Catalog No. ABIN1882280

Product Details anti-SUMO2 Antibody

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This SUMO2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Predicted Reactivity: B, C, Ha, Pr, M, Pig

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified His-tagged SUMO2 protein was used to produced this monoclonal antibody.

Clone: 973CT8-1-1

Isotype: IgG2b

Application Details

Application Notes: IF: 1:25. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SUMO2 antibody (ABIN1882280)

Xu, Au: "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1." in: The Biochemical journal, Vol. 386, Issue Pt 2, pp. 325-30, (2005) (PubMed).

Reverter, Lima: "A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex." in: Structure (London, England : 1993), Vol. 12, Issue 8, pp. 1519-31, (2004) (PubMed).

Mannen, Tseng, Cho, Li: "Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene." in: Biochemical and biophysical research communications, Vol. 222, Issue 1, pp. 178-80, (1996) (PubMed).

Target Details for SUMO2

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Alternative Name: SUMO2 (SUMO2 Products)

Synonyms: HSMT3 antibody, SMT3B antibody, SMT3H2 antibody, SUMO3 antibody, Smt3A antibody, SMT3A antibody, SMT3H1 antibody, SUMO-3 antibody, Smt3B antibody, Smt3h2 antibody, sumo2 antibody, zgc:92241 antibody, SUMO2 antibody, SUMO-2 antibody, Smt3b antibody, hsmt3 antibody, smt3b antibody, smt3h2 antibody, sumo-2 antibody, PSMT3 antibody, ATSUMO2 antibody, MCO15.11 antibody, MCO15_11 antibody, SMALL UBIQUITIN-LIKE MODIFIER 2 antibody, SUM2 antibody, SUMO 2 antibody, small ubiquitin-like modifier 2 antibody, small ubiquitin-like modifier 2 antibody, small ubiquitin-like modifier 3 antibody, small ubiquitin-like modifier 2b antibody, small ubiquitin-related modifier 2 antibody, small ubiquitin-like modifier 2 S homeolog antibody, small ubiquitin-like modifier 2 L homeolog antibody, SUMO2 antibody, SUMO3 antibody, Sumo2 antibody, sumo2b antibody, LOC714892 antibody, sumo2.S antibody, sumo2.L antibody

Background: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

Molecular Weight: 10871

NCBI Accession: NP_001005849, NP_008868

UniProt: P61956

Pathways: Methionine Biosynthetic Process