COX6AH antibody, COXVIAH antibody, CoxVIaH antibody, VIaH antibody, cytochrome c oxidase subunit 6A2 antibody, cytochrome c oxidase subunit VIa polypeptide 2 antibody, COX6A2 antibody, Cox6a2 antibody
Background
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex.This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles.Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues.These two polypeptides share 66% amino acid sequence identity.[provided by RefSeq] Synonyms: COX6AH, COXVIAH