Junctophilin 1 antibody (C-Term)

Catalog No. ABIN1887049

Product Details anti-Junctophilin 1 Antibody

Target: Junctophilin 1 (JPH1)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Junctophilin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the carboxy terminus of human JPH1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Junctophilin 1

Target: Junctophilin 1 (JPH1)

Alternative Name: JPH1 (JPH1 Products)

Synonyms: JP-1 antibody, JP1 antibody, ENSMUSG00000054314 antibody, Jp1 antibody, bZ1M12.3 antibody, jph1 antibody, si:rp71-1m12.3 antibody, Jph1 antibody, junctophilin 1 antibody, junctophilin 1a antibody, junctophilin-1 antibody, JPH1 antibody, Jph1 antibody, jph1 antibody, jph1a antibody, LOC100547979 antibody

Background: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels.Junctophilins (JPs) are important components of the junctional complexes.JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM.Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons.JPH1 is essential for stabilizing the T-tubule and SR membranes to form junctions and provide an environment for the assembly of receptors such as the ryanodine receptor type 1 (RyR1).
Synonyms: Junctophilin 1, JP1, JP-1