TRIM30 antibody (C-Term)

Catalog No. ABIN1887160

Product Details anti-TRIM30 Antibody

Target: TRIM30 (Trim30) (Tripartite Motif Containing 30 (Trim30))

Binding Specificity: C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM30 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the carboxy terminus of the mouse TRIM30.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for TRIM30

Target: TRIM30 (Trim30) (Tripartite Motif Containing 30 (Trim30))

Alternative Name: TRIM30 (Trim30 Products)

Synonyms: RGD1563970 antibody, Rpt-1 antibody, Rpt1 antibody, Trim30 antibody, tripartite motif-containing 30 antibody, tripartite motif-containing 30A antibody, Trim30 antibody, Trim30a antibody

Background: TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses.The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region.Studies have shown that some TRIM family members are critical to innate immunity, TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection.A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NF-kappaB activation.The importance of TRIM30 in the attenuation or termination of NF-kappaB activation suggests that targeting of TAB2 and TAB3 by TRIM30alpha may be a mechanism for modulating many types of immune responses.
Synonyms: Tripartite motif-containing 30, Rpt-1, Rpt1, down regulatory protein of interleukin 2 receptor

NCBI Accession: NP_033125