SPRED2 antibody (Center)

Catalog No. ABIN1887499

Product Details anti-SPRED2 Antibody

Target: SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPRED2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3.

Purification: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid peptide near the center of the human Spred2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SPRED2

Target: SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))

Alternative Name: Spred2 (SPRED2 Products)

Synonyms: SPRED2 antibody, Xspred2 antibody, spred-2 antibody, Xtspred2 antibody, spred2 antibody, wu:fb93f08 antibody, zgc:77284 antibody, Spred-2 antibody, C79158 antibody, sprouty related EVH1 domain containing 2 antibody, sprouty related, EVH1 domain containing 2 antibody, sprouty-related, EVH1 domain containing 2b antibody, sprouty-related, EVH1 domain containing 2 antibody, SPRED2 antibody, spred2 antibody, spred2b antibody, Spred2 antibody

Background: Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development.Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf.The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis.Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC.At least two isoforms of Spred2 are known to exist.
Synonyms: Sprouty-related EVH1 domain-containing protein 2

NCBI Accession: NP_861449