PRICKLE2 antibody (Center)

Catalog No. ABIN1887562

Product Details anti-PRICKLE2 Antibody

Target: PRICKLE2 (Prickle Homolog 2 (PRICKLE2))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRICKLE2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Two isoforms of PRICKLE2 are known to exist. PRICKLE2 antibody is predicted to not cross-react with other PRICKLE protein family members.

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the center of human PRICKLE2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for PRICKLE2

Target: PRICKLE2 (Prickle Homolog 2 (PRICKLE2))

Alternative Name: PRICKLE2 (PRICKLE2 Products)

Synonyms: EPM5 antibody, 6230400G14Rik antibody, 6720451F06Rik antibody, mpk2 antibody, cb886 antibody, im:7138215 antibody, pk2 antibody, prickle planar cell polarity protein 2 antibody, prickle homolog 2b antibody, PRICKLE2 antibody, Prickle2 antibody, prickle2b antibody

Background: PRICKLE2, also known as Pk2 or EPM5, is a member of a highly conserved protein family that function in the noncanonical WNT signaling pathway which regulates intracellular calcium release and planar cell polarity.Both PRICKLE2 and the related protein PRICKLE1 are expressed in postmitotic neurons and promote neurite outgrowth , and both proteins promote neurite outgrowth via the Dishevelled dependent pathway in C1300 cells.PRICKLE2 localizes to the postsynaptic density and interacts with PSD-95 and NMDA receptors.Defects in the gene encoding PRICKLE2 are associated with autosomal recessive progressive myoclonic epilepsy.
Synonyms: REST, NRSF-interacting LIM domain protein 1, Pk2, EPM5

NCBI Accession: NP_942559