FAM120A antibody (Center)

Catalog No. ABIN1887747

Product Details anti-FAM120A Antibody

Target: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM120A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity (Details): This antibody will not cross-reacti with FAM120B / PGCC1.

Purification: Affinity chromatography purified via peptide column

Immunogen: FAM120A antibody was raised against an 18 amino acid peptide from near the center of human FAM120A.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for FAM120A

Target: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Alternative Name: FAM120A (FAM120A Products)

Synonyms: MGC89333 antibody, fam120a antibody, C9orf10 antibody, Ossa antibody, DNAPTP1 antibody, DNAPTP5 antibody, OSSA antibody, RGD1306643 antibody, family with sequence similarity 120A antibody, family with sequence similarity 120, member A antibody, fam120a antibody, Fam120a antibody, FAM120A antibody

Background: FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31.FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain.As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling.It may participate in mRNA transport in the cytoplasm.FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase.FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress.Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.
Synonyms: Constitutive coactivator of PPAR-gamma-like protein 1, DNAPTP1, DNAPTP5, Oxidative stress-associated Src activator, OSSA

NCBI Accession: NP_055427