UNC93B1 antibody (N-Term)

Catalog No. ABIN1888104

Product Details anti-UNC93B1 Antibody

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC93B1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity (Details): Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide from near the amino terminus of human Unc93b.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for UNC93B1

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Alternative Name: Unc93b (UNC93B1 Products)

Synonyms: UNC93 antibody, IIAE1 antibody, UNC93B antibody, Unc-93B1 antibody, Unc93b antibody, unc-93 homolog B1, TLR signaling regulator antibody, unc-93 homolog B1 (C. elegans) antibody, UNC93B1 antibody, Unc93b1 antibody

Background: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C.elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling.Unlike Unc93a, another homolog of the C.elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9, the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction.Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
Synonyms: Unc93b1, homolog of C.elegans Unc93

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades