LZTS2 antibody (N-Term)

Catalog No. ABIN1888112

Product Details anti-LZTS2 Antibody

Target: LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LZTS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): LZTS2 antibody is predicted to not cross-react with other LZTS family members

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human LZTS2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for LZTS2

Target: LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2))

Alternative Name: LZTS2 (LZTS2 Products)

Synonyms: lapser1 antibody, MGC89253 antibody, si:dkey-250a11.1 antibody, LAPSER1 antibody, BC014695 antibody, mKIAA1813 antibody, Lapser1 antibody, leucine zipper, putative tumor suppressor 2 antibody, leucine zipper tumor suppressor 2 antibody, leucine zipper, putative tumor suppressor 2a antibody, leucine zipper, putative tumor suppressor 2 S homeolog antibody, lzts2 antibody, LZTS2 antibody, lzts2a antibody, Lzts2 antibody, lzts2.S antibody

Background: The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway.It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome.LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon.LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.
Synonyms: Leucine zipper putative tumor suppressor 2, LAPSER1

NCBI Accession: NP_115805