SPG11 antibody

Catalog No. ABIN1888237

Product Details anti-SPG11 Antibody

Target: SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPG11 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide of human SPG11.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SPG11

Target: SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))

Alternative Name: SPG11 (SPG11 Products)

Synonyms: 6030465E24Rik antibody, A330015I11 antibody, C530005A01Rik antibody, KIAA1840 antibody, RGD1562529 antibody, SPG11, spatacsin vesicle trafficking associated antibody, Spg11 antibody, SPG11 antibody

Background: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.? Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration.Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC.Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage.It is expressed in all structures of the brain, with a high expression in the cerebellum.SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC.Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene.? Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.
Synonyms: Spastic paraplegia 11, colorectal carcinoma-associated protein, spatacsin