ErbB2/Her2 antibody (pSer1107)
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- Target See all ErbB2/Her2 Antibodies
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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Binding Specificity
- pSer1107
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ErbB2/Her2 antibody is un-conjugated
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Application
- Western Blotting (WB), Dot Blot (DB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1107 of human ERBB2.
- Clone
- RB40102
- Isotype
- Ig Fraction
- Top Product
- Discover our top product ErbB2/Her2 Primary Antibody
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- Application Notes
- WB: 1:1000. DB: 1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Expiry Date
- 6 months
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The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." in: Cancer investigation, Vol. 28, Issue 9, pp. 969-77, (2010) (PubMed).
: "ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 43, pp. 18517-22, (2010) (PubMed).
: "Prognostic significance of HER-2/neu expression in patients with ductal carcinoma in situ." in: The Israel Medical Association journal : IMAJ, Vol. 12, Issue 5, pp. 290-5, (2010) (PubMed).
: "
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The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." in: Cancer investigation, Vol. 28, Issue 9, pp. 969-77, (2010) (PubMed).
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- Target
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
- Alternative Name
- ERBB2 (ErbB2/Her2 Products)
- Synonyms
- CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Erbb-2 antibody, Neu antibody, c-erbB2 antibody, c-neu antibody, mKIAA3023 antibody, wu:fv70f10 antibody, zgc:63601 antibody, erb2 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody, Erbb2 antibody, erbb2 antibody
- Background
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
- Molecular Weight
- 137910
- Gene ID
- 2064
- NCBI Accession
- NP_001005862, NP_004439
- UniProt
- P04626
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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