USP5 antibody

Catalog No. ABIN1944895

Product Details anti-USP5 Antibody

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This USP5 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.

Clone: 1340CT704-170-140

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-USP5 antibody (ABIN1944895)

Falquet, Paquet, Frutiger, Hughes, Hoang-Van, Jaton: "cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)." in: FEBS letters, Vol. 376, Issue 3, pp. 233-7, (1996) (PubMed).

Target Details for USP5

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Alternative Name: USP5 (USP5 Products)

Synonyms: ISOT antibody, AA407472 antibody, ISOT-1 antibody, Ucht antibody, ubiquitin specific peptidase 5 antibody, ubiquitin carboxyl-terminal hydrolase 5 antibody, ubiquitin carboxyl-terminal hydrolase 5, putative antibody, ubiquitin specific protease 5 antibody, ubiquitin specific peptidase 5 (isopeptidase T) antibody, USP5 antibody, CNH02890 antibody, EHI_049940 antibody, CC1G_12961 antibody, MCYG_01862 antibody, CGB_L3600C antibody, PY00546 antibody, Usp5 antibody

Background: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Molecular Weight: 95786

Gene ID: 8078

UniProt: P45974