SHC3 antibody

Catalog No. ABIN1944948

Product Details anti-SHC3 Antibody

Target: SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHC3 antibody is un-conjugated

Application: Western Blotting (WB)

Isotype: IgG

Application Details

Application Notes: WB - 1:1000

Restrictions: For Research Use only

Handling

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

References for anti-SHC3 antibody (ABIN1944948)

Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, (2004) (PubMed).

Liu, Meakin: "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases." in: The Journal of biological chemistry, Vol. 277, Issue 29, pp. 26046-56, (2002) (PubMed).

Nakamura, Sanokawa, Sasaki, Ayusawa, Oishi, Mori: "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway." in: Oncogene, Vol. 13, Issue 6, pp. 1111-21, (1996) (PubMed).

Pelicci, Dente, De Giuseppe, Verducci-Galletti, Giuli, Mele, Vetriani, Giorgio, Pandolfi, Cesareni, Pelicci: "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions." in: Oncogene, Vol. 13, Issue 3, pp. 633-41, (1996) (PubMed).

Target Details for SHC3

Target: SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))

Alternative Name: SHC3 (SHC3 Products)

Synonyms: N-Shc antibody, NSHC antibody, RAI antibody, SHCC antibody, ShcC antibody, Rai antibody, SHC adaptor protein 3 antibody, src homology 2 domain-containing transforming protein C3 antibody, SHC3 antibody, Shc3 antibody

Background: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Synonyms: SHC-transforming protein 3, Neuronal Shc, N-Shc, Protein Rai, SHC-transforming protein C, Src homology 2 domain-containing-transforming protein C3, SH2 domain protein C3, SHC3, NSHC, SHCC

Molecular Weight: 64056 Da

Gene ID: 53358

UniProt: Q92529

Pathways: RTK Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway