PIGR antibody (Polymeric Immunoglobulin Receptor) (AA 1-638)

Details for Product anti-PIGR Antibody No. ABIN1995773, Supplier: Log in to see
Antigen
  • DKFZp469G1013
  • RNPIGR2
  • pIgA-R
  • polymeric immunoglobulin receptor
  • PIGR
  • Pigr
Epitope
AA 1-638, Extracellular Domain
12
9
7
7
6
6
6
5
5
5
5
5
4
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
78
29
24
18
3
2
2
1
1
Host
Rabbit
133
8
2
Clonality
Polyclonal
Conjugate
This PIGR antibody is un-conjugated
23
16
6
2
2
2
Application
ELISA
116
60
38
22
18
18
13
12
8
2
2
1
1
1
1
Options
Supplier
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Immunogen Recombinant Human PIGR protein (ABIN2002143)
Isotype IgG
Specificity Human PIGR / Poly-Ig receptor
Characteristics Produced in rabbits immunized with purified, recombinant Human PIGR extracellular domain (rh PIGR, ABIN2002143 NP_002635.2, Met 1-Arg 638,. Total IgG was purified by Protein A affinity chromatography.
Purification purified by Protein A affinity chromatography
Sterility 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others PIGR products on genomics-online (e.g. as negative or positive controls)
Alternative Name PIGR (PIGR Antibody Abstract)
Background Polymeric immunoglobulin receptor, also known as,PIGR, is a member of the immunoglobulin superfamily,and a,Fc receptor. The ectodomain of this receptor consists of five units with homology to the variable units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. PIGR is expressed on several glandular epithelia including those of liver and breast. The deduced amino-acid sequence has a length of 764 residues and shows an overall similarity of 56% and 64% with the rabbit and rat counterpart. PIGR mediates transcellular transport of polymeric immunoglobulin molecules, and thus facilitates the secretion of,IgA,and,IgM. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment of PIGR.
NCBI Accession NP_002635.2
Application Notes ELISA: 0.5-1.0 μg/mL
This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human PIGR. The detection limit for Human PIGR is 0.00245 ng/well.
Restrictions For Research Use only
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months
Background publications Kaetzel: "Polymeric Ig receptor: defender of the fort or Trojan horse?" in: Current biology : CB, Vol. 11, Issue 1, pp. R35-8, 2001 (PubMed).

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