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IFNA5 antibody (Interferon, alpha 5) (AA 1-189) Primary Antibody

IFNA5 Reactivity: Human ELISA Host: Rabbit Polyclonal
Catalog No. ABIN1996487
$183.12
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  • Target
    Binding Specificity
    AA 1-189
    Reactivity
    Human
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This IFNA5 antibody is un-conjugated
    Application
    ELISA
    Specificity
    Human IFNA5 / IFNaG
    Characteristics
    Produced in rabbits immunized with purified, recombinant Human IFNA5 / IFNaG (rh IFNA5 / IFNaG, P01569, Met1-Glu189,. Total IgG was purified by Protein A affinity chromatography.
    Purification
    purified by Protein A affinity chromatography
    Sterility
    0.2 μm filtered
    Immunogen
    Recombinant Human IFNA5 / IFNaG protein
    Isotype
    IgG
  • Target
    Alternative Name
    IFNA5 (IFNA5 Antibody Abstract)
    Background
    Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by a wide variety of cells types in response to challenges by foreign agents such as viruses, parasites and tumor cells. There are three major classes of IFNs according to the receptor type through which they signal, and the type I IFNs bind to a specific receptor complex known as the IFN-α receptor (IFNAR) consisting of IFNAR1 and IFNAR2 chains. The type I IFNs present in humans are IFN-α, IFN-β and IFN-ω, and the IFN-α come in 13 subtypes whose encoding genes locate in a cluster on chromosome 9. IFN-α is produced by leukocytes and mainly involved in innate immune response against viral infection together with other IFNs. IFN-α is produced in response to the presence of dsRNA, a key indicator of viral infection via Toll Like Receptors, and assists the immune response by inhibiting viral replication within host cells, activating natural killer cells and macrophages, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection. IFN-α also acts as a pyrogenic factor and thus causes fever by binding to opioid receptors and eliciting the release of prostaglandin-E2, and serves as an analgesic by employing the similar mechanism. Furthermore, IFN-α is suggested to promote apoptosis and accordingly has therapeutic effect against certain cancers by inducing increased production of the p53 gene product. Here, the IFN-α G referrs to the human IFNA5 subtype.
    UniProt
    P01569
    Pathways
    JAK-STAT Signaling, Hepatitis C
  • Application Notes
    ELISA: 0.5-1 μg/mL
    This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IFNA5 / IFNaG. The detection limit for Human IFNA5 / IFNaG is approximately ≤ 0.039 ng/well.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    0.2 μm filtered solution in PBS with 5 % trehalose
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
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