APOE antibody (Apolipoprotein E) (AA 19-317)

Details for Product anti-APOE Antibody No. ABIN1997537, Supplier: Log in to see
Antigen
  • ad2
  • apoprotein
  • im:7036787
  • wu:fb69a05
  • zgc:110064
  • apoe
  • AI255918
  • AD2
  • LDLCQ5
  • LPG
  • APOEA
  • Apo-E
  • apolipoprotein E
  • apolipoprotein Ea
  • apoe
  • apoea
  • Apoe
  • APOE
Alternatives
anti-Mouse (Murine) APOE antibody for Immunodiffusion
Epitope
AA 19-317
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Reactivity
Human
311
95
51
7
7
3
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1
1
Host
Rabbit
164
106
94
1
Clonality
Polyclonal
Conjugate
This APOE antibody is un-conjugated
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Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
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Options
Supplier
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Supplier Product No.
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Immunogen Recombinant Human APOE / apolipoprotein E protein
Isotype IgG
Specificity Human APOE / apolipoprotein E
Characteristics Produced in rabbits immunized with purified, recombinant Human APOE / apolipoprotein E (rh APOE / apolipoprotein E, P02649, Lys 19-His 317,. APOE / apolipoprotein E specific IgG was purified by Human APOE / apolipoprotein E affinity chromatography.
Purification purified by affinity chromatography
Sterility 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others APOE products on genomics-online (e.g. as negative or positive controls)
Alternative Name APOE (APOE Antibody Abstract)
Background Apolipoprotein E (ApoE) is a 34.2 kDa glycosylated protein with 299 amino acid residues. ApoE is synthesized predominantly in the liver. Hepatic parenchyma cells are the main apoE producing cells in mammalian body, probably accounting for two thirds to three fourths of the plasma apoE. In the nervous system, apoE mRNA is present in neurons, astrocytes, ependymal cells, nonmyelinating Schwann cells. ApoE/Apolipoprotein E produced by mammalian cells exists in different forms, monomers, dimers, modified, unmodified, lipid- rich, and lipid-poor, and so forth. ApoE/Apolipoprotein E plays a double-role in immune responses. Both ApoE/Apolipoprotein E containing lipoproteins and multimers of synthetic apoE peptides inhibited proliferation of cultured lymphocytes by inhibiting DNA synthesis and reducing phospholipid turnover in T cells. ApoE/Apolipoprotein E can also affect innate and acquired immune responses in vitro by its ability to suppress stimulation of cultured neutrophils. ApoE/Apolipoprotein E can bind lipopolysaccharide (LPS), attenuate the inflammatory response, and thus reduce LPS induced lethality. Injection of LPS stimulated higher expression of inflammatory cytokines like interleukin (IL)-1, IL-12, and interferon-γ (IFN-γ), as well as IL-6.
UniProt P02649
Pathways Regulation of Cell Size, Lipid Metabolism
Application Notes ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ApoE. The detection limit for Human ApoE is approximately 0.00975 ng/well.
IHC-P: 0.1-2 μg/mL
Restrictions For Research Use only
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Apolipoprotein E (APOE) (AA 19-317) antibody (ABIN1997537) Immunochemical staining of human APOE in human liver with rabbit polyclonal antibody ...
Product cited in: Hu, Yao, Wang, Rong, Peng: "GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion." in: PLoS ONE, Vol. 9, Issue 3, pp. e90553, 2014 (PubMed).

Li, Jiang, Qu, Yao, Cai, Chen, Peng: "Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus." in: Journal of virology, Vol. 88, Issue 1, pp. 612-27, 2013 (PubMed).

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