ING5 antibody (Inhibitor of Growth Family, Member 5) (AA 36-84)

Details for Product anti-ING5 Antibody No. ABIN2000031
Antigen
  • p28ING5
  • 1700001C14Rik
  • 1700027H23Rik
  • 1810018M11Rik
  • AI225768
  • p28ing5
  • MGC76007
  • ING5
  • MGC133862
  • ING1
  • p33
  • si:busm1-40g1.1
  • si:dz40g1.1
  • wu:fc94a02
  • zgc:100910
  • ing5
  • inhibitor of growth family member 5
  • inhibitor of growth family, member 5
  • inhibitor of growth family member 5 L homeolog
  • inhibitor of growth family, member 5b
  • inhibitor of growth family, member 5a
  • ING5
  • Ing5
  • ing5
  • ing5.L
  • ing5b
  • ing5a
Epitope
AA 36-84
9
9
8
7
4
4
3
3
2
2
1
1
1
1
1
Reactivity
Human
63
10
5
1
1
1
1
1
1
1
Host
Rabbit
54
5
4
Clonality
Polyclonal
Conjugate
This ING5 antibody is un-conjugated
4
3
3
2
2
2
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
52
33
9
8
3
3
2
1
1
Options
Immunogen Recombinant Human ING5 protein (ABIN2005986)
Isotype IgG
Specificity Human ING5
Characteristics Produced in rabbits immunized with purified, recombinant Human ING5 (rh ING5, ABIN2005986 Q8WYH8-2, Glu36-Gln84,. ING5 specific IgG was purified by Human ING5 affinity chromatography.
Purification purified by affinity chromatography
Sterility 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others ING5 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name ING5 (ING5 Antibody Abstract)
Background ING5 is a member of the ING family. It is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING5 contains 1 PHD-type zinc finger. It can bind TP EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. ING5 is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. ING5 also is a component of the MOZ/MORF complex which is composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. It interacts with EP300 and TP53. MOZ/MORF complex has a histone H3 acetyltransferase activity. Through chromatin acetylation ING5 may regulate DNA replication and may function as a transcriptional coactivator. It interacts with H3K4me3 and to a lesser extent with H3K4me2.
UniProt Q8WYH8-2
Pathways Chromatin Binding
Application Notes WB: 2-10 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ING5. The detection limit for Human ING5 is approximately 0.00245 ng/well.
Restrictions For Research Use only
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months
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