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GADD34 antibody (AA 401-500)

PPP1R15A Reactivity: Human, Mouse, Rat WB, ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2174278
  • Target See all GADD34 (PPP1R15A) Antibodies
    GADD34 (PPP1R15A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A))
    Binding Specificity
    • 15
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reactivity
    • 29
    • 18
    • 17
    • 5
    • 3
    • 3
    • 1
    Human, Mouse, Rat
    Host
    • 27
    • 2
    • 2
    Rabbit
    Clonality
    • 28
    • 2
    Polyclonal
    Conjugate
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GADD34 antibody is un-conjugated
    Application
    • 30
    • 16
    • 12
    • 12
    • 10
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GADD34
    Isotype
    IgG
    Top Product
    Discover our top product PPP1R15A Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Yu, Cui, Zong, Gao, Xu, Gao, Chen, Qin, Guan, Liu, Fu, Li, Wang: "The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis." in: The Journal of biological chemistry, Vol. 290, Issue 34, pp. 20687-99, (2015) (PubMed).

  • Target
    GADD34 (PPP1R15A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A))
    Alternative Name
    GADD34 (PPP1R15A Products)
    Synonyms
    9630030H21 antibody, Gadd34 antibody, Myd116 antibody, GADD34 antibody, Peg-3 antibody, RGD1624209 antibody, protein phosphatase 1 regulatory subunit 15A antibody, protein phosphatase 1, regulatory (inhibitor) subunit 15A antibody, protein phosphatase 1, regulatory subunit 15A antibody, PPP1R15A antibody, Ppp1r15a antibody
    Background

    Synonyms: GADD34, Protein phosphatase 1 regulatory subunit 15A, Growth arrest and DNA damage-inducible protein GADD34, Myeloid differentiation primary response protein MyD116 homolog, PPP1R15A

    Background: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.

    Gene ID
    23645
    UniProt
    O75807
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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