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MAGI1 antibody (AA 161-260) (Alexa Fluor 488)

MAGI1 Reactivity: Rat WB, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 488
Catalog No. ABIN2177494
  • Target See all MAGI1 Antibodies
    MAGI1 (Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 1 (MAGI1))
    Binding Specificity
    • 14
    • 9
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 161-260
    Reactivity
    • 26
    • 16
    • 2
    Rat
    Host
    • 36
    • 4
    Rabbit
    Clonality
    • 38
    • 2
    Polyclonal
    Conjugate
    • 14
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAGI1 antibody is conjugated to Alexa Fluor 488
    Application
    • 35
    • 22
    • 12
    • 12
    • 12
    • 6
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse,Dog,Cow,Sheep,Pig,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MAGI1
    Isotype
    IgG
    Top Product
    Discover our top product MAGI1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MAGI1 (Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 1 (MAGI1))
    Alternative Name
    MAGI1/IRSP58 (MAGI1 Products)
    Synonyms
    CNKSR3 antibody, AIP-3 antibody, AIP3 antibody, BAIAP1 antibody, BAP-1 antibody, BAP1 antibody, MAGI-1 antibody, TNRC19 antibody, WWP3 antibody, Baiap1 antibody, Gukmi1 antibody, MAGI1c antibody, Magi-1 antibody, mKIAA4129 antibody, membrane associated guanylate kinase, WW and PDZ domain containing 1 antibody, MAGI1 antibody, Magi1 antibody
    Background

    Synonyms: AIP 3, AIP3, Atrophin 1 interacting protein 3, atrophin-1 interacting protein 3, BAI associated protein 2, BAI1 associated protein 1, BAI1-associated protein 1, BAIAP 1, BAIAP1, BAP 1, BAP1, BAP2, Brain specific angiogenesis inhibitor 1 associated protein 2, Fas ligand associated factor 3, FLAF3,Gukmi1, Insulin receptor substrate p53, Insulin receptor substrate p53/p58, Insulin receptor substrate protein of 53 kDa, IRS 58, IRSP53, IRSp53/58, MAGI 1, MAGI-1, MAGI1c, Membrane associated guanylate kinase inverted 1, membrane associated guanylate kinase inverted-1, membrane associated guanylate kinase WW and PDZ domain containing 1, Protein BAP2, TNRC 19, TNRC19, Trinucleotide repeat containing gene 19, Trinucleotide repeat containing gene 19 protein,trinucleotide repeat-containing gene 19, WW domain containing protein 3, WW domain-containing protein 3, WWP 3, WWP3.

    Background: The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains, however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.

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