IL1RN antibody

Catalog No. ABIN2191920

Product Details anti-IL1RN Antibody

Target: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL1RN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Sterility: 0.2 μm filtered

Clone: 2D11

Application Details

Application Notes: For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-IL1RN antibody (ABIN2191920)

Muzio, Polentarutti, Facchetti, Peri, Doni, Sironi, Transidico, Salmona, Introna, Mantovani: "Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra." in: European journal of immunology, Vol. 29, Issue 3, pp. 781-8, (1999) (PubMed).

Muzio, Polentarutti, Sironi, Poli, De Gioia, Introna, Mantovani, Colotta: "Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist." in: The Journal of experimental medicine, Vol. 182, Issue 2, pp. 623-8, (1995) (PubMed).

Target Details for IL1RN

Target: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Alternative Name: Il-1ra3 (IL1RN Products)

Synonyms: DIRA antibody, ICIL-1RA antibody, IL-1RN antibody, IL-1ra antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MVCD4 antibody, IRAP1 antibody, IL1RN antibody, IL-1RA antibody, F630041P17Rik antibody, interleukin 1 receptor antagonist antibody, interleukin 1 receptor antagonist-like antibody, IL1RN antibody, Il1rn antibody, IL1RNL antibody

Background: The antibody reacts specificly with Human IL-1ra3. IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro- inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.

Pathways: NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints