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Leptin Receptor antibody

LEPR Reactivity: Human WB, IHC (p), IHC (fro), IA Host: Mouse Monoclonal 2F1 unconjugated
Catalog No. ABIN2192046
  • Target See all Leptin Receptor (LEPR) Antibodies
    Leptin Receptor (LEPR)
    Reactivity
    • 114
    • 71
    • 50
    • 20
    • 12
    • 5
    • 4
    • 2
    Human
    Host
    • 117
    • 14
    • 2
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 114
    • 23
    Monoclonal
    Conjugate
    • 50
    • 11
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    This Leptin Receptor antibody is un-conjugated
    Application
    • 87
    • 47
    • 36
    • 36
    • 26
    • 26
    • 16
    • 10
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)
    Sterility
    0.2 μm filtered
    Clone
    2F1
    Top Product
    Discover our top product LEPR Primary Antibody
  • Application Notes
    For Western blot, immuno assays and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Expiry Date
    12 months
  • van Dielen, van t Veer, Buurman, Greve: "Leptin and soluble leptin receptor levels in obese and weight-losing individuals." in: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 4, pp. 1708-16, (2002) (PubMed).

  • Target
    Leptin Receptor (LEPR)
    Abstract
    LEPR Products
    Synonyms
    CD295 antibody, LEP-R antibody, LEPRD antibody, OB-R antibody, OBR antibody, obr antibody, cd295 antibody, ob-rb antibody, Fa antibody, LEPROT antibody, Leprb antibody, Modb1 antibody, OB-RGRP antibody, Obr antibody, db antibody, diabetes antibody, obese-like antibody, obl antibody, ObRb antibody, Ob-R antibody, Ob-RM antibody, lepr antibody, leptin receptor antibody, leptin receptor S homeolog antibody, LEPR antibody, lepr antibody, Lepr antibody, lepr.S antibody
    Background
    The monoclonal antibody 2F1 reacts with human soluble leptin receptor (sLR) in plasma. Leptin is a cytokine that is primarily expressed by adipose tissue. Leptin controls food intake by its interaction with the leptin receptor in the brain. Leptin action is mediated and controlled by the leptin receptor, a class I type cytokine receptor. sLR is generated by proteolytic cleavage of membrane-anchored receptors. This indicates that the leptin receptor might have other functions besides transduction. Binding of leptin with sLR increases the bioavailability of leptin in plasma, but also decreases the binding of leptin to membrane bound leptin receptors. For example, when comparing obese and lean individuals, plasma levels of sLR are significantly decreased whereas leptin levels are significantly increased. The monoclonal antibody 2F1 specifically reacts with sLR with a molecular mass of 180kD. The 2F1 antibody can be used to measure in both free sLR and sLR bound to leptin in plasma.
    Pathways
    JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour
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