TJP1 antibody (Tight Junction Protein 1 (Zona Occludens 1))

Details for Product anti-TJP1 Antibody No. ABIN2192206, Supplier: Log in to see
Antigen
  • ZO-1
  • ZO1
  • zo1
  • tight junction protein 1
  • tight junction protein ZO-1
  • TJP1
  • Tjp1
  • LOC396567
Alternatives
anti-Human TJP1 antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Human
99
37
33
19
11
5
4
4
3
2
1
1
1
1
Host
Rabbit
80
17
4
2
2
Clonality
Polyclonal
Conjugate
This TJP1 antibody is un-conjugated
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF)
84
34
28
24
21
14
13
12
12
8
7
7
1
1
1
Options
Supplier
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Sterility 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others TJP1 products on genomics-online (e.g. as negative or positive controls)
Alternative Name Zona Occludens 1 (TJP1 Antibody Abstract)
Background The polyclonal antibody recognizes human zona occludens 1 (ZO-1), an ~220 kDa tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family are involved in epithelial and endothelial intercellular junctions. They each contain at least one PSD95/Dlg/ZO-1 (PDZ) domain, a Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase domain. PDZ domains are 90-amino acid protein-protein binding domains that recognize at least a 3-residue peptide motif in the COOH termini of their binding partners. PDZ domain- containing proteins, like ZO-1, typically act as scaffolding proteins that organize membrane receptors and cytosolic proteins into multimeric signaling complexes often at the sites of cell-cell contact. The effectiveness and
Pathways Carbohydrate Homeostasis, Cell-Cell Junction Organization
Application Notes For immunfluorescence and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50..
Restrictions For Research Use only
Buffer PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Expiry Date 12 months
Product cited in: Balda, Anderson: "Two classes of tight junctions are revealed by ZO-1 isoforms." in: The American journal of physiology, Vol. 264, Issue 4 Pt 1, pp. C918-24, 1993 (PubMed).

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