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Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (C-Term) Primary Antibody

CASP6 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Pubmed (1)
Catalog No. ABIN222958
$340.00
Plus shipping costs $45.00
100 μg
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  • Target
    Caspase 6 (CASP6)
    Biological Activity
    Active
    Binding Specificity
    active, C-Term, Large Subunit
    • 32
    • 26
    • 16
    • 15
    • 15
    • 9
    • 9
    • 8
    • 7
    • 7
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human, Mouse, Rat
    • 180
    • 78
    • 72
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This Caspase 6 antibody is un-conjugated
    • 92
    • 19
    • 14
    • 11
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    Application
    Western Blotting (WB)
    • 153
    • 83
    • 76
    • 40
    • 37
    • 17
    • 14
    • 9
    • 5
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    Specificity
    The antibody detects the large subunit (18 kDa) of the active caspase-6.
    The antibody does not recognize other caspases.
    Purification
    Affinity purified
    Immunogen
    Synthetic peptide surrounding AA mapping to the C-terminus of the large fragment of human caspase-6
    Isotype
    IgG
  • Application Notes
    Western blotting (0.5-4 μg/mL) and immunofluorescence. However, the optimal conditions should be determined individually. The antibody detects the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize other caspases.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    100 μg (0.5 mg/mL) affinity purified rabbit anti-active caspase-6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    The antibody solution should be gently mixed before use.
    Storage
    -20 °C
    Storage Comment
    For long-term storage, aliquot and freeze at -70 °C.
    Expiry Date
    12 months
  • Vohra, Sasaki, Miller, Chang, DiAntonio, Milbrandt: "Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 41, pp. 13729-38, 2010 (PubMed).

  • Target
    Caspase 6 (CASP6)
    Alternative Name
    Caspase-6 (CASP6 Antibody Abstract)
    Synonyms
    xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6, Mch2, mCASP-6, MCH2, caspase 6 L homeolog, caspase 6, caspase 6, apoptosis-related cysteine peptidase, group XIIA secretory phospholipase A2, caspase-6, casp6.L, casp6, CASP6, CpipJ_CPIJ017008, Casp6
    Background
    Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase-3, caspase-6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
    Synonyms: CASP6, CASP-6 , MCH2
    Gene ID
    839
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis
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