Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1) antibody Primary Antibody
MLL1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal
Catalog No. ABIN223468
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- Human, Mouse
- Western Blotting (WB)
- The antibody recognizes the MLL1 of human and mouse origins.
Reactivity to other species has not been tested.
- Affinity purified
- Synthetic peptide of human MLL1
- Application Notes
- Western blotting (1:500 - 1:2000). However, the optimal concentrations should be determined individually. K562 nuclear extract can be used as a positive control. The antibody recognizes the MLL1 of human and mouse origins. Reactivity to other species has not been tested.
- For Research Use only
- 100 μL affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA and 0.01 % thimerosal.
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- The antibody solution should be gently mixed before use.
- -20 °C
- Storage Comment
- For long-term storage, aliquot and freeze at -70 °C.
- Expiry Date
- 12 months
- Alternative Name
- MLL1 (MLL1 Antibody Abstract)
- Mll, Mll1, 6430520K01, ALL-1, All1, Cxxc7, HRX, HTRX1, mKIAA4050, lysine methyltransferase 2A, lysine (K)-specific methyltransferase 2A, Kmt2a
- Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromosome 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia, also designated ALL-1 and HRX) regulates embryonal and hematopoietic development.
Synonyms: MLL, MLL1, myeloid/lymphoid or mixed-lineage leukemia, HRX, TRX1, HTRX1, human trithorax 1, ALL-1, acute lymphocytic leukemia 1, CXXC7, HGNC:7132
- Gene ID
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