ASAP3 antibody

Catalog No. ABIN233800

Product Details anti-ASAP3 Antibody

Target: ASAP3 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASAP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: This antibody was prepared from whole rabbit serum produced by repeated immunizations with recombinant human UPLC1/ASAP3 protein.
Immunogentype:Recombinant

Isotype: IgG

Application Details

Application Notes: This protein A purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 100 kDa in size corresponding to UPLC1/ASAP3 protein by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-ASAP3 antibody (ABIN233800)

Luo, Kong, Wang, Chen, Liu, Wang, Xu, Wang, Yang: "Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration." in: Molecular medicine reports, Vol. 9, Issue 2, pp. 387-94, (2014) (PubMed).

Target Details for ASAP3

Target: ASAP3 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3))

Alternative Name: Uplc1/Asap3 (ASAP3 Products)

Synonyms: DDEFL1 antibody, ddefl1 antibody, zgc:113885 antibody, ACAP4 antibody, CENTB6 antibody, UPLC1 antibody, 9430088F20Rik antibody, Ddefl1 antibody, Gm140 antibody, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 antibody, development and differentiation enhancing factor-like 1 antibody, ASAP3 antibody, asap3 antibody, DDEFL1 antibody, Asap3 antibody

Background: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Anti-UPLC1 (up-regulated in liver cancer 1) / ASAP3 Antibody, also named DDEFL1 (development and differentiation-enhancing factor-like 1) or ASAP3, is a member of the AZAP family of proteins. These proteins catalyze the hydrolysis of GTP bound to ADP-ribosylation factor (Arf) proteins, thereby causing Arf inactivation. For this reason, the ASAPs are generally called ArfGAPs.  The activity of ArfGAPs is dependent on the presence of phosphoinositides and is implicated in cellular processes such as membrane trafficking and remodeling of the actin cytoskeleton.  ASAP3 has been found to be up-regulated in 80% of the hepatocellular carcinomas examined.  Initial biochemical characterization reveals that ASAP3 shows class-specific GAP activity on Arf proteins, preferring Arf5 over Arf1 and Arf6. ASAP3 antibody has beed developed through the NCI antibody collaboration program and is ideal for Cancer and Signal Transduction research.
Synonyms: ASAP3 Antibody, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, FLJ20199 antibody, Gm140 antibody

Gene ID: 55616, 19071867

UniProt: Q8TDY4