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ATR antibody (Internal Region)

ATR Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN233834
  • Target See all ATR Antibodies
    ATR (ATR serine/threonine kinase (ATR))
    Binding Specificity
    • 11
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 46
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 40
    • 5
    • 2
    Rabbit
    Clonality
    • 43
    • 4
    Polyclonal
    Conjugate
    • 31
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATR antibody is un-conjugated
    Application
    • 25
    • 22
    • 19
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Monkey, Dog (Canine), Fish, Xenopus laevis
    Characteristics
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an of human ATR protein.
    Isotype
    IgG
    Top Product
    Discover our top product ATR Primary Antibody
  • Application Notes
    This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 301 kDa in size corresponding to ATR by western blotting in the appropriate cell lysate or extract.  Lysates from HeLa, U2OS, RAW264.7 or HEK293 cells are suggested for western blotting.  ATR is ubiquitously expressed, with highest expression levels in the testes.  Note that isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.28 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    ATR (ATR serine/threonine kinase (ATR))
    Alternative Name
    ATR (ATR Products)
    Synonyms
    FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR serine/threonine kinase antibody, ataxia telangiectasia and Rad3 related antibody, ATR antibody, Atr antibody
    Background
    Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidyl-inositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle.  ATR activates checkpoint signaling upon genotoxic stresses, such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor.  ATR is a member of the DNA-PK kinase family and is closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes, including histone deacetylases (HDAC1, HDAC2 and CHD4).  ATR is known to phosphorylate BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53 which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis.  ATR is a nuclear protein, but can also be found in PML nuclear bodies in certain cell types.  ATR is recruited to chromatin during S-phase and redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
    Synonyms: ACTR antibody, AIB1 antibody, amplified in breast cancer 1 antibody, Ataxia Telangiecasia and Rad3 Related antibody, CAGH16 antibody, CBP interacting protein antibody, CTG26 antibody, FRAP Related Protein 1 antibod
    Gene ID
    545, 157266317
    UniProt
    Q13535
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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