CYP21A2 antibody

Catalog No. ABIN2423245

Product Details anti-CYP21A2 Antibody

Target: CYP21A2 (Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP21A2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human CYP21A2

Isotype: IgG

Application Details

Application Notes: IHC 1:100-1:300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CYP21A2

Target: CYP21A2 (Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))

Alternative Name: CYP21A2 (CYP21A2 Products)

Synonyms: CA21H antibody, CAH1 antibody, CPS1 antibody, CYP21 antibody, CYP21B antibody, P450c21B antibody, 21-OH antibody, 21OH antibody, 21OHA antibody, 21OHB antibody, CYP21OH-A antibody, Cyp21 antibody, Cyp21-ps1 antibody, Cyp21B antibody, Cyp21a2-ps antibody, Cyp21a2ps antibody, Oh21-1 antibody, Oh21-2 antibody, CYP21A antibody, 21-OHase antibody, cytochrome P450 family 21 subfamily A member 2 antibody, cytochrome P450, family 21, subfamily a, polypeptide 1 antibody, cytochrome P450c21 antibody, cytochrome P450, family 21, subfamily A, polypepide 2 antibody, cytochrome P450, family 21, subfamily A, polypeptide 2 antibody, steroid 21-hydroxylase-like antibody, CYP21A2 antibody, Cyp21a1 antibody, LOC101094596 antibody

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene, gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process