GADD45B antibody

Catalog No. ABIN2423503

Product Details anti-GADD45B Antibody

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GADD45B antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human GADD45B

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GADD45B

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Alternative Name: GADD45B (GADD45B Products)

Synonyms: GADD45BETA antibody, MYD118 antibody, AI323528 antibody, Myd118 antibody, CS131 antibody, cb196 antibody, gadd45b antibody, gadd45b2 antibody, sb:cb196 antibody, zgc:73104 antibody, gadd45beta antibody, wu:fa92d10 antibody, wu:fa98h12 antibody, wu:fk65h03 antibody, zgc:111973 antibody, gadd45b1 antibody, gadd45bl antibody, zgc:112453 antibody, growth arrest and DNA damage inducible beta antibody, growth arrest and DNA-damage-inducible 45 beta antibody, growth arrest and DNA-damage-inducible, beta antibody, growth arrest and DNA-damage-inducible, beta a antibody, growth arrest and DNA-damage-inducible, beta b antibody, GADD45B antibody, Gadd45b antibody, gadd45ba antibody, gadd45bb antibody

Background: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

Pathways: Cell Division Cycle