LIG-1 antibody, LIG1 antibody, D6Bwg0781e antibody, Img antibody, leucine rich repeats and immunoglobulin like domains 1 antibody, leucine-rich repeats and immunoglobulin-like domains 1 antibody, LRIG1 antibody, Lrig1 antibody
Background
Leucine rich repeat protein,Leucine rich repeat protein LRIG1,leucine rich repeats and immunoglobulin like domains 1,Leucine-rich repeats and immunoglobulin-like domains protein 1,leucine-rich repeats- and immunoglobulin-like domains-cotnaining protein 1,LIG 1,LIG-1,LIG1,Lrig1,LRIG1,Ortholog of mouse integral membrane glycoprotein LIG 1,Leucine-rich repeats and immunoglobulin-like domains protein 1is aproteinthat in humans is encoded by theLRIG1gene.It encodes atransmembrane proteinthat has been shown to interact with receptor tyrosine kinases of theEGFR-family,METandRET. Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.