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Nephrin antibody

NPHS1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2426273
  • Target See all Nephrin (NPHS1) Antibodies
    Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))
    Reactivity
    • 80
    • 49
    • 28
    • 15
    Human, Mouse, Rat
    Host
    • 82
    • 5
    • 2
    • 1
    Rabbit
    Clonality
    • 81
    • 9
    Polyclonal
    Conjugate
    • 38
    • 10
    • 8
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Nephrin antibody is un-conjugated
    Application
    • 39
    • 37
    • 19
    • 18
    • 16
    • 11
    • 9
    • 8
    • 7
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Purification
    Affinity purification
    Immunogen
    Synthetic peptide of human NPHS1
    Isotype
    IgG
    Top Product
    Discover our top product NPHS1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:25-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Preservative
    Sodium azide
    Handling Advice
    Avoid freeze / thaw cycles.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))
    Alternative Name
    NPHS1 (NPHS1 Products)
    Synonyms
    NPHS1 antibody, nphs1l antibody, nphs1 antibody, CNF antibody, NPHN antibody, nephrin antibody, NephrinB antibody, NPHS1, nephrin antibody, nephrosis 1, congenital, Finnish type (nephrin) antibody, NPHS1 nephrin S homeolog antibody, nephrin antibody, NPHS1 nephrin antibody, nephrosis 1, nephrin antibody, NPHS1 antibody, nphs1 antibody, nphs1.S antibody, LOC5579127 antibody, Nphs1 antibody
    Background
    CNF,Nephrin,Nephrosis 1 congenital Finnish type,Nephrosis 1,congenital,Finnish type (nephrin),NPHN,NPHN,NPHS 1,Nphs1,Renal glomerulus specific cell adhesion receptor,Renal glomerulus-specific cell adhesion receptor,This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180- kDa protein in lysates of human glomeruli and a 150- kDa protein in transfected COS-7 cell lysates.
    Molecular Weight
    Calculated MW: 135 kDa
    NCBI Accession
    NP_004637
    Pathways
    Regulation of Actin Filament Polymerization, Skeletal Muscle Fiber Development
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