PTAFR antibody

Catalog No. ABIN2432185

Product Details anti-PTAFR Antibody

Target: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTAFR antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Synthetic peptide of human PTAFR

Isotype: IgG

Application Details

Application Notes: IHC 1:25-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PTAFR

Target: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Alternative Name: PTAFR (PTAFR Products)

Synonyms: PAFR antibody, MGC52896 antibody, MGC160177 antibody, PAFr antibody, pafr antibody, PAF-R antibody, platelet activating factor receptor antibody, platelet-activating factor receptor antibody, platelet activating factor receptor L homeolog antibody, PTAFR antibody, Ptafr antibody, ptafr.L antibody, ptafr antibody

Background: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

NCBI Accession: NP_000943

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin