CHRDL2 antibody

Catalog No. ABIN2434460

Product Details anti-CHRDL2 Antibody

Target: CHRDL2 (Chordin-Like 2 (CHRDL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRDL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity purification

Immunogen: Synthetic peptide of human CHRDL2

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CHRDL2

Target: CHRDL2 (Chordin-Like 2 (CHRDL2))

Alternative Name: CHRDL2 (CHRDL2 Products)

Synonyms: BNF1 antibody, CHL2 antibody, FKSG37 antibody, 1810022C01Rik antibody, Chl2 antibody, chl antibody, si:dkey-11j5.7 antibody, si:dkey-11j5.7-like antibody, chordin like 2 antibody, chordin-like 2 antibody, CHRDL2 antibody, Chrdl2 antibody, chrdl2 antibody

Background: CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.

Molecular Weight: Calculated MW: 48 kDa

NCBI Accession: NP_056239